In September 2009, the National Institutes of Health (NIH) released the new "Enhancing Peer Review" guidelines for research grant structure and content. Beginning in 2010, most R, K, and F grant types must be restructured to fit within half the space previously allotted for the research plan. While streamlining peer review, the newly redesigned grant structure requires a different approach to grant writing. In this seminar, we explore the NIH research grant with its restructured content, and present a strategy for writing the grant. We specifically dissect the new research section and discuss many common mistakes investigators make in writing this section of the grant. We also address grant organization, aesthetics, and aspects of language and writing important to presentation. Overall, we present a strategy of grant writing that will improve investigator grantsmanship.